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Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

Many cellular functions necessary for life are tightly regulated by protein allosteric conformational change, and correlated dynamics between protein regions has been found to contribute to the function of proteins not previously considered allosteric. The ability to map and control such dynamic cou...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Proctor, Elizabeth A., Kota, Pradeep, Aleksandrov, Andrei A., He, Lihua, Riordan, John R., Dokholyan, Nikolay V.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324596/
https://ncbi.nlm.nih.gov/pubmed/25685315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01320d
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