Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder. Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. Whether klotho can counter...

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Publié dans:J Neurosci
Auteurs principaux: Dubal, Dena B., Zhu, Lei, Sanchez, Pascal E., Worden, Kurtresha, Broestl, Lauren, Johnson, Erik, Ho, Kaitlyn, Yu, Gui-Qiu, Kim, Daniel, Betourne, Alexander, Kuro-o, Makoto, Masliah, Eliezer, Abraham, Carmela R., Mucke, Lennart
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323521/
https://ncbi.nlm.nih.gov/pubmed/25673831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5791-12.2015
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