Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder. Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. Whether klotho can counter...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Dubal, Dena B., Zhu, Lei, Sanchez, Pascal E., Worden, Kurtresha, Broestl, Lauren, Johnson, Erik, Ho, Kaitlyn, Yu, Gui-Qiu, Kim, Daniel, Betourne, Alexander, Kuro-o, Makoto, Masliah, Eliezer, Abraham, Carmela R., Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323521/
https://ncbi.nlm.nih.gov/pubmed/25673831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5791-12.2015
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