Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder. Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. Whether klotho can counter...

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發表在:J Neurosci
Main Authors: Dubal, Dena B., Zhu, Lei, Sanchez, Pascal E., Worden, Kurtresha, Broestl, Lauren, Johnson, Erik, Ho, Kaitlyn, Yu, Gui-Qiu, Kim, Daniel, Betourne, Alexander, Kuro-o, Makoto, Masliah, Eliezer, Abraham, Carmela R., Mucke, Lennart
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2015
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323521/
https://ncbi.nlm.nih.gov/pubmed/25673831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5791-12.2015
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