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Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder. Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. Whether klotho can counter...
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| 發表在: | J Neurosci |
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| Main Authors: | , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Society for Neuroscience
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4323521/ https://ncbi.nlm.nih.gov/pubmed/25673831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5791-12.2015 |
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