Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene. Previous investigations have identified that depletion of Ataxin-10, the gene product, leads to cellular apoptosis and cytokinesis failure. Herein we identify the mitotic...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tian, Jie, Tian, Chuan, Ding, Yuehe, Li, Zhe, Geng, Qizhi, Xiahou, Zhikai, Wang, Jue, Hou, Wenya, Liao, Ji, Dong, Meng-Qiu, Xu, Xingzhi, Li, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322367/
https://ncbi.nlm.nih.gov/pubmed/25666058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08360
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