Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene. Previous investigations have identified that depletion of Ataxin-10, the gene product, leads to cellular apoptosis and cytokinesis failure. Herein we identify the mitotic...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Tian, Jie, Tian, Chuan, Ding, Yuehe, Li, Zhe, Geng, Qizhi, Xiahou, Zhikai, Wang, Jue, Hou, Wenya, Liao, Ji, Dong, Meng-Qiu, Xu, Xingzhi, Li, Jing
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322367/
https://ncbi.nlm.nih.gov/pubmed/25666058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08360
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