Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs

Non-steroidal anti-inflammatory drugs prevent colorectal cancer by inhibiting cyclooxygenase (COX) enzymes that synthesize tumor-promoting prostaglandins. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a tumor suppressor that degrades tumor-promoting prostaglandins. Murine knockout of 15-PGDH in...

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Bibliographic Details
Published in:Carcinogenesis
Main Authors: Fink, Stephen P., Dawson, Dawn M., Zhang, Yongyou, Kresak, Adam, Lawrence, Earl G., Yang, Peiying, Chen, Yanwen, Barnholtz-Sloan, Jill S., Willis, Joseph E., Kopelovich, Levy, Markowitz, Sanford D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322189/
https://ncbi.nlm.nih.gov/pubmed/25503930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu241
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