15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors

Pharmacologic inhibitors of the prostaglandin-synthesizing COX-2 oncogene prevent the development of premalignant human colon adenomas. However, resistance to treatment is common. In this study, we show that the adenoma prevention activity of the COX-2 inhibitor celecoxib requires the concomitant pr...

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Detalhes bibliográficos
Main Authors: Yan, Min, Myung, Seung-Jae, Fink, Stephen P., Lawrence, Earl, Lutterbaugh, James, Yang, Peiying, Zhou, Xiaohua, Liu, Danielle, Rerko, Ronald M., Willis, Joseph, Dawson, Dawn, Tai, Hsin-Hsiung, Barnholtz-Sloan, Jill S., Newman, Robert A., Bertagnolli, Monica M., Markowitz, Sanford D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2695050/
https://ncbi.nlm.nih.gov/pubmed/19470469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902367106
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