15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and...

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Detalhes bibliográficos
Main Authors: Myung, Seung-Jae, Rerko, Ronald M., Yan, Min, Platzer, Petra, Guda, Kishore, Dotson, Angela, Lawrence, Earl, Dannenberg, Andrew J., Lovgren, Alysia Kern, Luo, Guangbin, Pretlow, Theresa P., Newman, Robert A., Willis, Joseph, Dawson, Dawn, Markowitz, Sanford D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567703/
https://ncbi.nlm.nih.gov/pubmed/16880406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603235103
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