15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we demonstrate that 15-PGDH is active in vivo as a highly potent suppressor of colon neoplasia development and...

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Bibliographische Detailangaben
Hauptverfasser: Myung, Seung-Jae, Rerko, Ronald M., Yan, Min, Platzer, Petra, Guda, Kishore, Dotson, Angela, Lawrence, Earl, Dannenberg, Andrew J., Lovgren, Alysia Kern, Luo, Guangbin, Pretlow, Theresa P., Newman, Robert A., Willis, Joseph, Dawson, Dawn, Markowitz, Sanford D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567703/
https://ncbi.nlm.nih.gov/pubmed/16880406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603235103
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