Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory cells throughout the small and large intestine. Although median survival of m...

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Autores principales: Zhou, Dawang, Zhang, Yongyou, Wu, Hongtan, Barry, Evan, Yin, Yi, Lawrence, Earl, Dawson, Dawn, Willis, Joseph E., Markowitz, Sanford D., Camargo, Fernando D., Avruch, Joseph
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241824/
https://ncbi.nlm.nih.gov/pubmed/22042863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110428108
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