Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

Ablation of the kinases Mst1 and Mst2, orthologs of the Drosophila antiproliferative kinase Hippo, from mouse intestinal epithelium caused marked expansion of an undifferentiated stem cell compartment and loss of secretory cells throughout the small and large intestine. Although median survival of m...

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Autori principali: Zhou, Dawang, Zhang, Yongyou, Wu, Hongtan, Barry, Evan, Yin, Yi, Lawrence, Earl, Dawson, Dawn, Willis, Joseph E., Markowitz, Sanford D., Camargo, Fernando D., Avruch, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241824/
https://ncbi.nlm.nih.gov/pubmed/22042863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110428108
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