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YAP oncogene overexpression supercharges colon cancer proliferation
The transcriptional co-activator YAP is an evolutionarily conserved regulator of organ size and progenitor cell proliferation. YAP is overexpressed at high frequency in many common human cancers and can directly drive cancer development in mouse models. YAP abundance and nuclear localization are neg...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3335916/ https://ncbi.nlm.nih.gov/pubmed/22356765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.6.19453 |
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