The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells

The Mst1 and Mst2 protein kinases are the mammalian homologs of hippo, a major inhibitor of cell proliferation in Drosophila. Mst1 is most abundant in lymphoid tissues. Mice lacking Mst1 exhibit markedly reduced levels of the Mst1 regulatory protein Nore1B/RAPL in lymphoid cells, whereas Mst2 abunda...

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Detalhes bibliográficos
Main Authors: Zhou, Dawang, Medoff, Benjamin D., Chen, Lanfen, Li, Lequn, Zhang, Xian-feng, Praskova, Maria, Liu, Matthew, Landry, Aimee, Blumberg, Richard S., Boussiotis, Vassiliki A., Xavier, Ramnik, Avruch, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600581/
https://ncbi.nlm.nih.gov/pubmed/19073936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810773105
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