Structural plasticity of methyllysine recognition by the tandem Tudor domain of 53BP1

p53 is dynamically regulated through various posttranslational modifications (PTMs), which differentially modulate its function and stability. The dimethylated marks p53K370me2 and p53K382me2 are associated with p53 activation or stabilization and both are recognized by the tandem Tudor domain (TTD)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Structure
Prif Awduron: Tong, Qiong, Cui, Gaofeng, Botuyan, Maria Victoria, Rothbart, Scott B., Hayashi, Ryo, Musselman, Catherine A., Singh, Namit, Appella, Ettore, Strahl, Brian D., Mer, Georges, Kutateladze, Tatiana G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321732/
https://ncbi.nlm.nih.gov/pubmed/25579814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.11.013
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