Imaging the distribution of polymyxins in the kidney

OBJECTIVES: Dose-limiting nephrotoxicity remains the Achilles' heel of polymyxin B and polymyxin E (also known as colistin), which are important last-line antibiotics used against infections caused by MDR Gram-negative ‘superbugs’. An understanding of the mechanisms of nephrotoxicity, including...

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Vydáno v:J Antimicrob Chemother
Hlavní autoři: Yun, Bo, Azad, Mohammad A. K., Wang, Jiping, Nation, Roger L., Thompson, Philip E., Roberts, Kade D., Velkov, Tony, Li, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319485/
https://ncbi.nlm.nih.gov/pubmed/25377569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku441
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