Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation

GDF8, or myostatin, is a member of the TGF-β superfamily of secreted polypeptide growth factors. GDF8 is a potent negative regulator of myogenesis both in vivo and in vitro. We found that GDF8 signaling was inhibited by the small molecule ATP competitive inhibitors dorsomorphin and LDN-193189. These...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Horbelt, Daniel, Boergermann, Jan H., Chaikuad, Apirat, Alfano, Ivan, Williams, Eleanor, Lukonin, Ilya, Timmel, Tobias, Bullock, Alex N., Knaus, Petra
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319009/
https://ncbi.nlm.nih.gov/pubmed/25368322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604397
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