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Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16
Leukemia stem cells (LSC) are resistant to conventional chemotherapy and persistent LSC after chemotherapy are supposed to be a major cause of relapse. However, information on genetic or epigenetic regulation of stem cell properties is still limited and LSC-targeted drugs have scarcely been identifi...
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Publicado en: | Cancer Sci |
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Autores principales: | , , , , , , |
Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4317832/ https://ncbi.nlm.nih.gov/pubmed/24612037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12386 |
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