Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

Leukemia stem cells (LSC) are resistant to conventional chemotherapy and persistent LSC after chemotherapy are supposed to be a major cause of relapse. However, information on genetic or epigenetic regulation of stem cell properties is still limited and LSC-targeted drugs have scarcely been identifi...

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Vydáno v:Cancer Sci
Hlavní autoři: Ueda, Koki, Yoshimi, Akihide, Kagoya, Yuki, Nishikawa, Satoshi, Marquez, Victor E, Nakagawa, Masahiro, Kurokawa, Mineo
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317832/
https://ncbi.nlm.nih.gov/pubmed/24612037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12386
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