Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia

In acute myeloid leukemia (AML), therapy resistance occurs frequently and leads to high mortality of the disease. However, the mechanisms that render leukemic cells drug resistant remain largely undefined. Here, we identified loss of the histone methyltransferase EZH2 and subsequent reduction of his...

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Publicado no:Nat Med
Main Authors: Göllner, Stefanie, Oellerich, Thomas, Agrawal-Singh, Shuchi, Schenk, Tino, Klein, Hans-Ulrich, Rohde, Christian, Pabst, Caroline, Sauer, Tim, Lerdrup, Mads, Tavor, Sigal, Stölzel, Friedrich, Herold, Sylvia, Ehninger, Gerhard, Köhler, Gabriele, Pan, Kuan-Ting, Urlaub, Henning, Serve, Hubert, Dugas, Martin, Spiekermann, Karsten, Vick, Binje, Jeremias, Irmela, Berdel, Wolfgang E., Hansen, Klaus, Zelent, Arthur, Wickenhauser, Claudia, Müller, Lutz P., Thiede, Christian, Müller-Tidow, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548550/
https://ncbi.nlm.nih.gov/pubmed/27941792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4247
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