Loss of the Histone Methyltransferase EZH2 induces Resistance to Multiple Drugs in Acute Myeloid Leukemia

In acute myeloid leukemia (AML), therapy resistance occurs frequently and leads to high mortality of the disease. However, the mechanisms that render leukemic cells drug resistant remain largely undefined. Here, we identified loss of the histone methyltransferase EZH2 and subsequent reduction of his...

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Detaylı Bibliyografya
Yayımlandı:Nat Med
Asıl Yazarlar: Göllner, Stefanie, Oellerich, Thomas, Agrawal-Singh, Shuchi, Schenk, Tino, Klein, Hans-Ulrich, Rohde, Christian, Pabst, Caroline, Sauer, Tim, Lerdrup, Mads, Tavor, Sigal, Stölzel, Friedrich, Herold, Sylvia, Ehninger, Gerhard, Köhler, Gabriele, Pan, Kuan-Ting, Urlaub, Henning, Serve, Hubert, Dugas, Martin, Spiekermann, Karsten, Vick, Binje, Jeremias, Irmela, Berdel, Wolfgang E., Hansen, Klaus, Zelent, Arthur, Wickenhauser, Claudia, Müller, Lutz P., Thiede, Christian, Müller-Tidow, Carsten
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548550/
https://ncbi.nlm.nih.gov/pubmed/27941792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4247
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