Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage leukemia fusion leukemia through upregulation of p16

Leukemia stem cells (LSC) are resistant to conventional chemotherapy and persistent LSC after chemotherapy are supposed to be a major cause of relapse. However, information on genetic or epigenetic regulation of stem cell properties is still limited and LSC-targeted drugs have scarcely been identifi...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Ueda, Koki, Yoshimi, Akihide, Kagoya, Yuki, Nishikawa, Satoshi, Marquez, Victor E, Nakagawa, Masahiro, Kurokawa, Mineo
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317832/
https://ncbi.nlm.nih.gov/pubmed/24612037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12386
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