Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers

Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major drivers of human cancers through dysregulation of multiple growth and survival pathways. Similar to many other non-kinase oncogenes and tumor suppressors, efforts to directly target KRAS pharmaceutically have not yet materializ...

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Udgivet i:Cancer Sci
Main Authors: Ebi, Hiromichi, Faber, Anthony C, Engelman, Jeffrey A, Yano, Seiji
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4317830/
https://ncbi.nlm.nih.gov/pubmed/24612015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12383
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