Novel recurrently mutated genes in African American colon cancers

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in Af...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Guda, Kishore, Veigl, Martina L., Varadan, Vinay, Nosrati, Arman, Ravi, Lakshmeswari, Lutterbaugh, James, Beard, Lydia, Willson, James K. V., Sedwick, W. David, Wang, Zhenghe John, Molyneaux, Neil, Miron, Alexander, Adams, Mark D., Elston, Robert C., Markowitz, Sanford D., Willis, Joseph E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313860/
https://ncbi.nlm.nih.gov/pubmed/25583493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417064112
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