Novel recurrently mutated genes in African American colon cancers

We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in Af...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Guda, Kishore, Veigl, Martina L., Varadan, Vinay, Nosrati, Arman, Ravi, Lakshmeswari, Lutterbaugh, James, Beard, Lydia, Willson, James K. V., Sedwick, W. David, Wang, Zhenghe John, Molyneaux, Neil, Miron, Alexander, Adams, Mark D., Elston, Robert C., Markowitz, Sanford D., Willis, Joseph E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313860/
https://ncbi.nlm.nih.gov/pubmed/25583493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417064112
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