How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?

BACKGROUND: Next-generation sequencing technologies generate a significant number of short reads that are utilized to address a variety of biological questions. However, quite often, sequencing reads tend to have low quality at the 3’ end and are generated from the repetitive regions of a genome. It...

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Detalhes bibliográficos
Main Authors: Yu, Xiaoqing, Guda, Kishore, Willis, Joseph, Veigl, Martina, Wang, Zhenghe, Markowitz, Sanford, Adams, Mark D, Sun, Shuying
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414812/
https://ncbi.nlm.nih.gov/pubmed/22709551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0381-5-6
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