STEP(61) is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease

Parkinson’s disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). The loss of SNc dopaminergic neurons affects the plasticity of striatal neurons and leads to significant motor and cognitive disabilities during the progression of the d...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kurup, Pradeep K., Xu, Jian, Videira, Rita Alexandra, Ononenyi, Chimezie, Baltazar, Graça, Lombroso, Paul J., Nairn, Angus C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313846/
https://ncbi.nlm.nih.gov/pubmed/25583483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417423112
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