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Structurally related nucleotides as selective agonists and antagonists at P2Y(1) receptors

The P2Y(1) receptor responds to adenine nucleotides and is present in platelets, heart, smooth muscles prostate, ovary, and brain. A selective antagonist may be useful as an antithrombotic agent. We have analyzed the binding site of this G protein-coupled receptor using ligand design, site-directed...

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Détails bibliographiques
Publié dans:Farmaco
Auteurs principaux: Jacobson, Kenneth A., Moro, Stefano, Hoffmann, Carsten, Kim, Yong-Chul, Kim, Hak Sung, Ravi, R. Gnana, Harden, T. Kendall, Boyer, José L.
Format: Artigo
Langue:Inglês
Publié: 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313380/
https://ncbi.nlm.nih.gov/pubmed/11347970
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