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Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation: Enhanced Stability and Potency as P2Y(1) Receptor Agonists

Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5′-triphosphate agonists at P2Y(1), P2Y(2), P2Y(4), and P2Y(11) receptors, but not P2Y(6) receptors, was established using a ring-constrained methanocarba (a 3.1.0-bicyclohexane) ring as a ribose substitute (Kim et...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Ravi, R. Gnana, Kim, Hak Sung, Servos, Jörg, Zimmermann, Herbert, Lee, Kyeong, Maddileti, Savitri, Boyer, José L., Harden, T. Kendall, Jacobson, Kenneth A.
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959107/
https://ncbi.nlm.nih.gov/pubmed/11985476
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