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SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
Senescent cells develop a pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). As many SASP components affect surrounding cells and alter their microenvironment, SASP may be a key phenomenon in linking cellular senesence with individual aging and age-related disease...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4312089/ https://ncbi.nlm.nih.gov/pubmed/25635860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116480 |
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