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Suppression of p16 alleviates the senescence-associated secretory phenotype
Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis. OIS cells are also characterized by the e...
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| Publicado no: | Aging (Albany NY) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906185/ https://ncbi.nlm.nih.gov/pubmed/33550279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202640 |
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