Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling

Ornithine decarboxylase (ODC) is the key rate limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progre...

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Publié dans:Cancer Prev Res (Phila)
Auteurs principaux: Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Ritchie, Rebekah L., Brewer, Misty, Biddick, Laura, Patlolla, Jagan Mohan R., Sadeghi, Michael, Lightfoot, Stan, Steele, Vernon E., Rao, Chinthalapally V.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310684/
https://ncbi.nlm.nih.gov/pubmed/25248858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0176
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