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Eflornithine (DFMO) Prevents Progression of Pancreatic Cancer by Modulating Ornithine Decarboxylase Signaling

Ornithine decarboxylase (ODC) is the key rate limiting enzyme in the polyamine synthesis pathway and it is overexpressed in a variety of cancers. We found that polyamine synthesis and modulation of ODC signaling occurs at early stages of pancreatic precursor lesions and increases as the tumor progre...

詳細記述

保存先:
書誌詳細
出版年:Cancer Prev Res (Phila)
主要な著者: Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Ritchie, Rebekah L., Brewer, Misty, Biddick, Laura, Patlolla, Jagan Mohan R., Sadeghi, Michael, Lightfoot, Stan, Steele, Vernon E., Rao, Chinthalapally V.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310684/
https://ncbi.nlm.nih.gov/pubmed/25248858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0176
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