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EGFR inhibitor gefitinib prevents progression of pancreatic lesions to carcinoma in a conditional LSL-Kras(G12D/+) transgenic mice model

Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic malignancy with a dismal prognosis. Developing novel strategies to prevent/delay pancreatic cancer is currently of intense interest. The chemopreventive efficacy of gefitinib, an epidermal growth factor receptor (EGFR) inhibitor,...

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Detalhes bibliográficos
Main Authors: Mohammed, Altaf, Janakiram, Naveena B, Li, Qian, Madka, Venkateshwar, Ely, Misty, Lightfoot, Stan, Crawford, Howard, Steele, Vernon E., Rao, Chinthalapally V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058550/
https://ncbi.nlm.nih.gov/pubmed/21084261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0038
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