Mutational Analysis of the Ability of Resveratrol To Inhibit Amyloid Formation by Islet Amyloid Polypeptide: Critical Evaluation of the Importance of Aromatic–Inhibitor and Histidine–Inhibitor Interactions

[Image: see text] The process of amyloid formation by the normally soluble hormone islet amyloid polypeptide (IAPP) contributes to β-cell death in type 2 diabetes and in islet transplants. There are no clinically approved inhibitors of islet amyloidosis, and the mode of action of existing inhibitors...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Tu, Ling-Hsien, Young, Lydia M., Wong, Amy G., Ashcroft, Alison E., Radford, Sheena E., Raleigh, Daniel P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310630/
https://ncbi.nlm.nih.gov/pubmed/25531836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501016r
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