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Radiosynthesis and in Vivo Evaluation of Two PET Radioligands for Imaging α-Synuclein
Two α-synuclein ligands, 3-methoxy-7-nitro-10H-phenothiazine (2a, K(i) = 32.1 ± 1.3 nM) and 3-(2-fluoroethoxy)-7-nitro-10H-phenothiazine (2b, K(i) = 49.0 ± 4.9 nM), were radiolabeled as potential PET imaging agents by respectively introducing (11)C and (18)F. The syntheses of [(11)C]2a and [(18)F]2b...
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| 出版年: | Appl Sci (Basel) |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310556/ https://ncbi.nlm.nih.gov/pubmed/25642331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/app4010066 |
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