Radiosynthesis and in vivo evaluation of a novel σ(1) selective PET ligand

The σ(1) receptor is an important target for CNS disorders. We previously identified a σ(1) ligand TZ3108 having highly potent (K(i-σ1) = 0.48 nM) and selective affinity for σ(1) versus σ(2) receptors. TZ3108 was (18)F-labeled with F-18 for in vivo evaluation. Biodistribution and blocking studies of...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Jin, Hongjun, Fan, Jinda, Zhang, Xiang, Li, Junfeng, Flores, Hubert P., Perlmutter, Joel S., Parsons, Stanley M., Tu, Zhude
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4288033/
https://ncbi.nlm.nih.gov/pubmed/25584182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00240G
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