A GSK-3β inhibitor protects against radiation necrosis in mouse brain

PURPOSE/OBJECTIVES: To quantify the effectiveness of SB415286, a specific inhibitor of GSK-3β, as a neuroprotectant of radiation-induced, CNS (brain) necrosis in a mouse model. METHODS AND MATERIALS: Cohorts of mice were treated with SB415286 or DMSO prior to irradiation with a single 45-Gy fraction...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Radiat Oncol Biol Phys
Prif Awduron: Jiang, Xiaoyu, Perez-Torres, Carlos J., Thotala, Dinesh, Engelbach, John A., Yuan, Liya, Cates, Jeremy, Gao, Feng, Drzymala, Robert E., Rich, Keith M., Schmidt, Robert E., Ackerman, Joseph J.H., Hallahan, Dennis E., Garbow, Joel R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307920/
https://ncbi.nlm.nih.gov/pubmed/24969790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.04.018
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