Anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain

PURPOSE: To quantify the effectiveness of anti-VEGF antibodies (bevacizumab and B20-4.1.1) as mitigators of radiation-induced, CNS (brain) necrosis in a mouse model. EXPERIMENTAL DESIGN: Cohorts of mice were irradiated with single-fraction 50- or 60-Gy doses of radiation targeted to the left hemisph...

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Autors principals: Jiang, Xiaoyu, Engelbach, John A, Yuan, Liya, Cates, Jeremy, Gao, Feng, Drzymala, Robert E, Hallahan, Dennis E, Rich, Keith M, Schmidt, Robert E, Ackerman, Joseph JH, Garbow, Joel R
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135174/
https://ncbi.nlm.nih.gov/pubmed/24647570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1941
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