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A GSK-3β inhibitor protects against radiation necrosis in mouse brain
PURPOSE/OBJECTIVES: To quantify the effectiveness of SB415286, a specific inhibitor of GSK-3β, as a neuroprotectant of radiation-induced, CNS (brain) necrosis in a mouse model. METHODS AND MATERIALS: Cohorts of mice were treated with SB415286 or DMSO prior to irradiation with a single 45-Gy fraction...
שמור ב:
| הוצא לאור ב: | Int J Radiat Oncol Biol Phys |
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| Main Authors: | , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4307920/ https://ncbi.nlm.nih.gov/pubmed/24969790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.04.018 |
| תגים: |
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