A GSK-3β inhibitor protects against radiation necrosis in mouse brain

PURPOSE/OBJECTIVES: To quantify the effectiveness of SB415286, a specific inhibitor of GSK-3β, as a neuroprotectant of radiation-induced, CNS (brain) necrosis in a mouse model. METHODS AND MATERIALS: Cohorts of mice were treated with SB415286 or DMSO prior to irradiation with a single 45-Gy fraction...

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Publicat a:Int J Radiat Oncol Biol Phys
Autors principals: Jiang, Xiaoyu, Perez-Torres, Carlos J., Thotala, Dinesh, Engelbach, John A., Yuan, Liya, Cates, Jeremy, Gao, Feng, Drzymala, Robert E., Rich, Keith M., Schmidt, Robert E., Ackerman, Joseph J.H., Hallahan, Dennis E., Garbow, Joel R.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307920/
https://ncbi.nlm.nih.gov/pubmed/24969790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.04.018
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