Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

Polyglutamine expansion in androgen receptor (AR) is responsible for spinobulbar muscular atrophy (SBMA) that leads to selective loss of lower motor neurons. Using SBMA as a model, we explored the relationship between protein structure/function and neurodegeneration in polyglutamine diseases. We sho...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuron
Prif Awduron: Scaramuzzino, Chiara, Casci, Ian, Parodi, Sara, Lievens, Patricia M.J., Polanco, Maria J., Milioto, Carmelo, Chivet, Mathilde, Monaghan, John, Mishra, Ashutosh, Badders, Nisha, Aggarwal, Tanya, Grunseich, Christopher, Sambataro, Fabio, Basso, Manuela, Fackelmayer, Frank O., Taylor, J. Paul, Pandey, Udai Bhan, Pennuto, Maria
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305189/
https://ncbi.nlm.nih.gov/pubmed/25569348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.031
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