Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

Polyglutamine expansion in androgen receptor (AR) is responsible for spinobulbar muscular atrophy (SBMA) that leads to selective loss of lower motor neurons. Using SBMA as a model, we explored the relationship between protein structure/function and neurodegeneration in polyglutamine diseases. We sho...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuron
Hlavní autoři: Scaramuzzino, Chiara, Casci, Ian, Parodi, Sara, Lievens, Patricia M.J., Polanco, Maria J., Milioto, Carmelo, Chivet, Mathilde, Monaghan, John, Mishra, Ashutosh, Badders, Nisha, Aggarwal, Tanya, Grunseich, Christopher, Sambataro, Fabio, Basso, Manuela, Fackelmayer, Frank O., Taylor, J. Paul, Pandey, Udai Bhan, Pennuto, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305189/
https://ncbi.nlm.nih.gov/pubmed/25569348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.031
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky