Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

Polyglutamine expansion in androgen receptor (AR) is responsible for spinobulbar muscular atrophy (SBMA) that leads to selective loss of lower motor neurons. Using SBMA as a model, we explored the relationship between protein structure/function and neurodegeneration in polyglutamine diseases. We sho...

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Publicado en:Neuron
Main Authors: Scaramuzzino, Chiara, Casci, Ian, Parodi, Sara, Lievens, Patricia M.J., Polanco, Maria J., Milioto, Carmelo, Chivet, Mathilde, Monaghan, John, Mishra, Ashutosh, Badders, Nisha, Aggarwal, Tanya, Grunseich, Christopher, Sambataro, Fabio, Basso, Manuela, Fackelmayer, Frank O., Taylor, J. Paul, Pandey, Udai Bhan, Pennuto, Maria
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305189/
https://ncbi.nlm.nih.gov/pubmed/25569348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.031
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