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Structural and Kinetic Effects on Changes in the CO(2) Binding Pocket of Human Carbonic Anhydrase II
This work examines the effect on catalysis of perturbing the position of bound CO(2) in the active site of human carbonic anhydrase II (HCA II). Variants of HCA II replacing Val143 with hydrophobic residues, Ile, Leu, and Ala, were examined. The efficiency of catalysis in the hydration of CO(2) for...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4301431/ https://ncbi.nlm.nih.gov/pubmed/23098192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301155z |
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