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Structural and Kinetic Study of the Extended Active Site for Proton Transfer in Human Carbonic Anhydrase II
The catalysis of CO(2) hydration by human carbonic anhydrase II (HCA II) is limited in maximal velocity by proton transfer from a zinc-bound water molecule to the proton shuttle His64. This proton transfer occurs along a hydrogen-bonded water network, leading to the proton shuttle residue His64, whi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925223/ https://ncbi.nlm.nih.gov/pubmed/20578724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1007645 |
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