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Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation

Ribosome profiling data report on the distribution of translating ribosomes, at steady-state, with codon-level resolution. We present a robust method to extract codon translation rates and protein synthesis rates from these data, and identify causal features associated with elongation and translatio...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Syst Biol
Main Authors: Pop, Cristina, Rouskin, Silvi, Ingolia, Nicholas T, Han, Lu, Phizicky, Eric M, Weissman, Jonathan S, Koller, Daphne
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300493/
https://ncbi.nlm.nih.gov/pubmed/25538139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145524
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