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Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan

Aging of biological systems is accompanied by degeneration of mitochondrial functions. Different pathways are active to counteract the processes which lead to mitochondrial dysfunction. Mitochondrial dynamics, the fission and fusion of mitochondria, is one of these quality control pathways. Mitophag...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bernhardt, Dominik, Müller, Matthias, Reichert, Andreas S., Osiewacz, Heinz D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298727/
https://ncbi.nlm.nih.gov/pubmed/25601284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07885
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