Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

How chromatin shapes pathways that promote genome–epigenome integrity in response to DNA damage is an issue of crucial importance. We report that human bromodomain (BRD)-containing proteins, the primary “readers” of acetylated chromatin, are vital for the DNA damage response (DDR). We discovered tha...

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Vydáno v:Genes Dev
Hlavní autoři: Gong, Fade, Chiu, Li-Ya, Cox, Ben, Aymard, François, Clouaire, Thomas, Leung, Justin W., Cammarata, Michael, Perez, Mercedes, Agarwal, Poonam, Brodbelt, Jennifer S., Legube, Gaëlle, Miller, Kyle M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298138/
https://ncbi.nlm.nih.gov/pubmed/25593309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252189.114
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