Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

How chromatin shapes pathways that promote genome–epigenome integrity in response to DNA damage is an issue of crucial importance. We report that human bromodomain (BRD)-containing proteins, the primary “readers” of acetylated chromatin, are vital for the DNA damage response (DDR). We discovered tha...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Gong, Fade, Chiu, Li-Ya, Cox, Ben, Aymard, François, Clouaire, Thomas, Leung, Justin W., Cammarata, Michael, Perez, Mercedes, Agarwal, Poonam, Brodbelt, Jennifer S., Legube, Gaëlle, Miller, Kyle M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298138/
https://ncbi.nlm.nih.gov/pubmed/25593309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252189.114
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