Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination

How chromatin shapes pathways that promote genome–epigenome integrity in response to DNA damage is an issue of crucial importance. We report that human bromodomain (BRD)-containing proteins, the primary “readers” of acetylated chromatin, are vital for the DNA damage response (DDR). We discovered tha...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Gong, Fade, Chiu, Li-Ya, Cox, Ben, Aymard, François, Clouaire, Thomas, Leung, Justin W., Cammarata, Michael, Perez, Mercedes, Agarwal, Poonam, Brodbelt, Jennifer S., Legube, Gaëlle, Miller, Kyle M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2015
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298138/
https://ncbi.nlm.nih.gov/pubmed/25593309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.252189.114
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