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Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP

The dysregulation of glucose-inhibited glucagon secretion from the pancreatic islet α-cell is a critical component of diabetes pathology and metabolic disease. We show a previously uncharacterized [Ca(2+)](i)-independent mechanism of glucagon suppression in human and murine pancreatic islets whereby...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Endocrinol Metab
Asıl Yazarlar: Elliott, Amicia D., Ustione, Alessandro, Piston, David W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297778/
https://ncbi.nlm.nih.gov/pubmed/25406263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00344.2014
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