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Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP
The dysregulation of glucose-inhibited glucagon secretion from the pancreatic islet α-cell is a critical component of diabetes pathology and metabolic disease. We show a previously uncharacterized [Ca(2+)](i)-independent mechanism of glucagon suppression in human and murine pancreatic islets whereby...
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| izdano v: | Am J Physiol Endocrinol Metab |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297778/ https://ncbi.nlm.nih.gov/pubmed/25406263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00344.2014 |
| Oznake: |
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