Loss of Keratinocytic RXRα Combined with Activated CDK4 or oncogenic NRAS Generates UVB-induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment

Understanding the molecular mechanisms behind formation of melanoma, the deadliest form of skin cancer, is crucial for improved diagnosis and treatment. One key is to better understand the cross-talk between epidermal keratinocytes and pigment-producing melanocytes. Here, using a bigenic mouse model...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Coleman, Daniel J., Chagani, Sharmeen, Hyter, Stephen, Sherman, Anna M., Löhr, Christiane V., Liang, Xiaobo, Ganguli-Indra, Gitali, Indra, Arup K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297739/
https://ncbi.nlm.nih.gov/pubmed/25189354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0164
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