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Loss of Keratinocytic RXRα Combined with Activated CDK4 or oncogenic NRAS Generates UVB-induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment

Understanding the molecular mechanisms behind formation of melanoma, the deadliest form of skin cancer, is crucial for improved diagnosis and treatment. One key is to better understand the cross-talk between epidermal keratinocytes and pigment-producing melanocytes. Here, using a bigenic mouse model...

詳細記述

保存先:
書誌詳細
出版年:Mol Cancer Res
主要な著者: Coleman, Daniel J., Chagani, Sharmeen, Hyter, Stephen, Sherman, Anna M., Löhr, Christiane V., Liang, Xiaobo, Ganguli-Indra, Gitali, Indra, Arup K.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297739/
https://ncbi.nlm.nih.gov/pubmed/25189354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0164
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