Loss of Keratinocytic RXRα Combined with Activated CDK4 or oncogenic NRAS Generates UVB-induced Melanomas via Loss of p53 and PTEN in the Tumor Microenvironment

Understanding the molecular mechanisms behind formation of melanoma, the deadliest form of skin cancer, is crucial for improved diagnosis and treatment. One key is to better understand the cross-talk between epidermal keratinocytes and pigment-producing melanocytes. Here, using a bigenic mouse model...

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Détails bibliographiques
Publié dans:Mol Cancer Res
Auteurs principaux: Coleman, Daniel J., Chagani, Sharmeen, Hyter, Stephen, Sherman, Anna M., Löhr, Christiane V., Liang, Xiaobo, Ganguli-Indra, Gitali, Indra, Arup K.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297739/
https://ncbi.nlm.nih.gov/pubmed/25189354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0164
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