Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas

BACKGROUND: Understanding the underlying molecular mechanisms involved in the formation of cutaneous malignant melanoma is critical for improved diagnosis and treatment. Keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) has a protective role against melanomagenesis and is involved in the r...

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Publicado en:BMC Cancer
Autores principales: Chagani, Sharmeen, Wang, Rong, Carpenter, Evan L., Löhr, Christiane V., Ganguli-Indra, Gitali, Indra, Arup K.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679438/
https://ncbi.nlm.nih.gov/pubmed/29121869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3714-6
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